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Test Code LAB1385 Coccidioides Antibody, Complement Fixation and Immunodiffusion, Serum

Additional Codes

Mayo Test ID
SCOC

Reporting Name

Coccidioides Ab, CompF/ImmDiff, S

Useful For

Diagnosis of coccidioidomycosis using serum specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Ordering Guidance


This test is a confirmatory assay for positive screening tests (ie, enzyme immunoassay).

 

The recommended test to evaluate for possible Coccidioides infection is COXIS / Coccidioides Antibody Screen with Reflex, Serum.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.8 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

COMPLEMENT FIXATION

Negative

If positive, results are titered.

 

IMMUNODIFFUSION

Negative

Results are reported as positive, negative, or equivocal.

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86635 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SCOC Coccidioides Ab, CompF/ImmDiff, S 87435-4

 

Result ID Test Result Name Result LOINC Value
8295 Coccidioides Ab, CompF, S In Process
21649 Coccidioides, IgG, ImmDiff, S 62459-3
21648 Coccidioides, IgM, ImmDiff, S 62458-5

Interpretation

Complement Fixation:

Titer results of 1:2 or higher may suggest active disease; however, titers may persist for months after infection has resolved. Increasing complement fixation (CF) titer results in serial specimens are considered diagnostic of active disease.

 

Immunodiffusion:

The presence of IgM antibodies may be detectable within 2 weeks after the onset of symptoms; however, the antibody may be detected longer than 6 months after infection.

 

The presence of IgG antibodies parallels the CF antibodies and may suggest an active or a recent asymptomatic infection with Coccidioides immitis/posadasii; however, antibodies may persist after the infection has resolved.

 

An equivocal result (a band of nonidentity) cannot be interpreted as significant for a specific diagnosis. However, this may be an indication that a patient should be followed serologically.

 

Over 90% of primary symptomatic cases will be detected by combined immunodiffusion and CF testing.

Report Available

4 to 7 days

Specimen Retention Time

14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Method Name

Complement Fixation (CF)

Immunodiffusion

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.