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General Information:

Web Links:

Mayo Clinic Laboratories

Test Code LAB1381 Rufinamide, Serum

Additional Codes

Mayo Test ID
RUFI

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum rufinamide concentrations, assessing compliance, and adjusting dosage in patients receiving other drugs that interact pharmacokinetically with rufinamide (ie, drugs that induce liver CYP3A4 enzymes) and may be helpful in those who are receiving hemodialysis

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Rufinamide, S

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect blood immediately before next scheduled dose.

2. For sustained-release formulations ONLY, collect blood a minimum of 12 hours after last dose.

3. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

5.0-30.0 mcg/mL

Interpretation

The reference interval is broad and represents the concentrations observed to be associated with the greatest drug efficacy without side effects or toxicity.

Day(s) Performed

Tuesday, Thursday, Saturday

Report Available

3 to 5 days

Specimen Retention Time

14 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80210

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RUFI Rufinamide, S 59323-6

 

Result ID Test Result Name Result LOINC Value
63030 Rufinamide, S 59323-6

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Therapeutics Test Request (T831)

-Neurology Specialty Testing Client Test Request (T732)