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HelpTest Code LAB1154 Duloxetine, Serum
Additional Codes
| Mayo Test ID |
|---|
| DULOX |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring duloxetine serum concentration during therapy
Evaluating potential duloxetine toxicity
Evaluating patient compliance
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Duloxetine, SSpecimen Type
Serum RedSpecimen Required
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Draw blood immediately before the next scheduled dose (trough).
2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
30-120 ng/mLInterpretation
Therapeutic ranges are not well-established, but literature suggests that patients receiving duloxetine monotherapy for depression responded well when trough concentrations were 30 to 120 ng/mL. Higher levels may be tolerated by individual patients. The therapeutic relevance of this concentration range to other uses of duloxetine therapy is currently unknown.
Day(s) Performed
Wednesday
Report Available
1 to 8 daysSpecimen Retention Time
14 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DULOX | Duloxetine, S | 46227-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 89305 | Duloxetine, S | 46227-5 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.