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HelpTest Code LAB1100 C8 Complement, Functional, Serum
Additional Codes
| Mayo Test ID |
|---|
| C8FX |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Diagnosis of C8 deficiency
Investigation of a patient with an undetectable total hemolytic complement level
Method Name
Automated Liposome Lysis Assay
Reporting Name
C8 Complement, Functional, SSpecimen Type
Serum RedOrdering Guidance
The total complement assay (COM / Complement, Total, Serum) should be used as a screen for suspected complement deficiencies before ordering individual complement component assays. A deficiency of an individual component of the complement cascade will result in an undetectable total complement level.
Specimen Required
Patient Preparation: Fasting preferred
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Immediately after specimen collection, place the tube on wet ice.
2. Centrifuge and aliquot serum into plastic vial.
3. Immediately freeze specimen.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Frozen | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
33-58 U/mL
Interpretation
Low levels of complement may be due to inherited deficiencies, acquired deficiencies, or due to complement consumption (eg, as a consequence of infectious or autoimmune processes).
Absent C8 levels in the presence of normal C3 and C4 values are consistent with a C8 deficiency. Absent C8 levels in the presence of low C3 and C4 values suggests complement consumption.
Normal results indicate both normal C8 protein levels and normal functional activity.
Day(s) Performed
Monday through FridayReport Available
1 to 3 daysSpecimen Retention Time
14 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86161
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| C8FX | C8 Complement, Functional, S | 50997-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| C8FX | C8 Complement, Functional, S | 50997-6 |