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Test Code LAB1054 Alpha-Fetoprotein (AFP), Peritoneal Fluid

Additional Codes

Mayo Test ID
AFPPT

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

An adjunct to cytology to differentiate between malignancy-related ascites and benign causes of ascites formation

Method Name

Immunoenzymatic Assay

Reporting Name

AFP, Peritoneal Fluid

Specimen Type

Peritoneal


Specimen Required


Container/Tube: Plain, plastic, screw-top tube

Specimen Volume: 2 mL


Specimen Minimum Volume

0.5 mL (Samples <0.5 mL may be rejected)

Specimen Stability Information

Specimen Type Temperature Time Special Container
Peritoneal Frozen (preferred) 90 days
  Ambient  7 days
  Refrigerated  7 days

Reject Due To

Gross hemolysis Reject
Gross icterus OK

Reference Values

An interpretive report will be provided.

Interpretation

A peritoneal fluid alpha-fetoprotein (AFP) concentration greater than 6.0 ng/mL is suspicious but not diagnostic of ascites related to hepatocellular carcinoma (HCC). This clinical decision limit cutoff yielded a sensitivity of 58%, specificity of 96% in a study of 137 patients presenting with ascites. AFP concentrations were significantly higher in ascites caused by HCC. Ascites caused by malignancies other than HCC routinely had AFP concentrations less than 6.0 ng/mL. Therefore, negative results should be interpreted with caution.

Day(s) Performed

Monday through Saturday

Report Available

1 to 3 days

Specimen Retention Time

12 months

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86316

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AFPPT AFP, Peritoneal Fluid 49761-0

 

Result ID Test Result Name Result LOINC Value
AFPPN AFP, Peritoneal Fluid 49761-0
SITEF Site 39111-0

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.