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HelpTest Code LAB0298604 Inflammatory Bowel Disease Serology Panel, Serum
Additional Codes
| Mayo Test ID |
|---|
| IBDP2 |
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and imaging evaluations
This test is not useful for determining the extent of disease in patients with inflammatory bowel disease or determining the response to disease-specific therapy including surgical resection of diseased intestine.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ANCA2 | Cytoplasmic Neutrophilic Ab IBD, S | No | Yes |
| SCERA | Saccharomyces cerevisiae Ab, IgA, S | Yes | Yes |
| SCERG | Saccharomyces cerevisiae Ab, IgG, S | Yes | Yes |
Method Name
SCERA, SCERG: Enzyme-Linked Immunosorbent Assay (ELISA)
ANCA2: Indirect Immunofluorescent Assay (IFA)
Reporting Name
Inflammatory Bowel Disease Panel, SSpecimen Type
SerumSpecimen Minimum Volume
0.8 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimen | Reject |
Reference Values
Saccharomyces cerevisiae ANTIBODY, IgA
Negative: <20.0 RU/mL
Positive: ≥20.0 RU/mL
Saccharomyces cerevisiae ANTIBODY, IgG
Negative: <20.0 RU/mL
Positive: ≥20.0 RU/mL
CYTOPLASMIC NEUTROPHIL ANTIBODIES, INFLAMMATORY BOWEL DISEASE PANEL, SERUM
Negative (not detectable)
Interpretation
The presence of antineutrophil cytoplasmic antibodies in the absence of IgA and IgG anti-Saccharomyces cerevisiae antibodies is consistent with the diagnosis of ulcerative colitis; the presence of IgA and IgG ASCA in the absence of ANCA is consistent with Crohn disease.
Day(s) Performed
Monday through Friday
Report Available
3 to 7 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86671 x 2
86036
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IBDP2 | Inflammatory Bowel Disease Panel, S | 87551-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 610030 | Cytoplasmic Neutrophilic Ab IBD, S | 17355-9 |
| SCERA | Saccharomyces cerevisiae Ab, IgA, S | 47320-7 |
| SCERG | Saccharomyces cerevisiae Ab, IgG, S | 47321-5 |
| 614542 | ANCA2 Interpretation | 49308-0 |
Forms
If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Test Request (T728) with the specimen.
Testing Algorithm
For more information see Inflammatory Bowel Disease Diagnostic Testing Algorithm.
For more information see Ulcerative Colitis and Crohn Disease Therapeutic Drug Monitoring Algorithm.