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Test Code LAB0292664 Antimicrobial Susceptibility, Nocardia species and other Aerobic Actinomycetes, Varies

Infectious

Additional Codes

Mayo Test ID
MMLNS

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Determining the resistance of species of Nocardia and other aerobic actinomycetes to antimicrobial agents.

 

This test is not useful for determining resistance of aerobic actinomycetes species of the following genera: Actinoallomurus, Actinocatenispora, Actinoplanes, Aeromicrobium, Croceifilum, Hazenella, Intrasporangium, Kineosphaera, Kitasatospora, Kribella, Kutzneria, Laceyella, Marinactinospora, Microbispora, Micromonospora, Nocardioides (not Nocardia), Phycicoccus, Piscicoccus, Prauserella, Risungbinella, Saccharothrix, Sphaerimonospora, Spirillospora, Streptosporangium, Terracoccus, or Thermoactinomyces.

Testing Algorithm

When this test is ordered, susceptibility for Nocardia species will be performed at an additional charge.

 

When the organism identification is Rhodococcus equi the additional reflex test will be performed at an additional charge for the additional antimicrobials vancomycin and rifampin.

Method Name

Minimum Inhibitory Concentration (MIC)

Reporting Name

Susc, Aerobic Actinomycetes

Specimen Type

Varies


Ordering Guidance


This test is intended for assessing antimicrobial susceptibility of Nocardia species and other pathogenic aerobic actinomycetes which include the more commonly isolated genera of Rhodococcus, Streptomyces, Gordonia, Dietzia, Tsukamurella, and Williamsia species, as well as the lesser isolated genera which include Actinomadura, Amycolatopsis, Dermatophilus, Kroppenstedtia, Nocardiopsis, Nonomuraea, Pseudonocardia, Saccharomonospora, and Saccharopolyspora species.

 

Certain genera of aerobic actinomycetes will not be accepted for susceptibility testing. Aerobic actinomycetes genera that will not be tested include the following: Actinoallomurus, Actinocatenispora, Actinoplanes, Aeromicrobium, Croceifilum, Hazenella, Intrasporangium, Kineosphaera, Kitasatospora, Kribella, Kutzneria, Laceyella, Marinactinospora, Microbispora, Micromonospora, Nocardioides (not Nocardia), Phycicoccus, Piscicoccus, Prauserella, Risungbinella, Saccharothrix, Sphaerimonospora, Spirillospora, Streptosporangium, Terracoccus, and Thermoactinomyces.



Additional Testing Requirements


If organism identification is not provided, CTB / Mycobacteria and Nocardia Culture, Varies or CTBID / Culture Referred for Identification, Mycobacterium and Nocardia, Varies must also be ordered and will be charged separately.



Shipping Instructions


1. For shipping information see Infectious Specimen Shipping Guidelines.

2. Place specimen in a large infectious container and label as an etiologic agent/infectious substance.



Necessary Information


1. Specimen source is required.

2. Organism identification is required unless either CTB / Mycobacteria and Nocardia Culture, Varies or CTBID / Culture Referred for Identification, Mycobacterium and Nocardia, Varies is also ordered.



Specimen Required


Specimen Type: Organism in pure culture

Supplies: Infectious Container, Large (T146)

Container/Tube:

Preferred: Middlebrook 7H10 agar slant without antimicrobials

Acceptable: Sabouraud's dextrose agar slant or similar media without antimicrobials (eg, 7H11 agar slant, LJ, MGIT [7H9] broth media)

Specimen Volume: Isolate

Collection Instructions: Organism must be in pure culture, actively growing.


Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
  Refrigerated 

Reject Due To

Agar plate Reject

Reference Values

Interpretive criteria and reporting guidelines are followed using the Clinical Laboratory Standards Institute (CLSI) M24S document.

Interpretation

Interpretive values for susceptibility testing of Nocardia species using a broth microdilution method are included in the report, as appropriate.

 

For Rhodococcus equi, the interpretive values for vancomycin and rifampin will also be included.

 

See Reference Values for additional information.

Day(s) Performed

Monday through Sunday

Report Available

12 to 28 days

Specimen Retention Time

2 years

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87186

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MMLNS Susc, Aerobic Actinomycetes 29577-4

 

Result ID Test Result Name Result LOINC Value
MMLNS Susc, Aerobic Actinomycetes 29577-4

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SSNS Susceptibility Nocardia species No, (Bill Only) Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
MIC Susceptibility, MIC No, (Bill Only) No

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.