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HelpTest Code LAB0291658 Immunoglobulin Total Light Chains, Urine
Additional Codes
| Mayo Test ID |
|---|
| TLCU |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring patients whose urine demonstrates large M-spikes
Confirming the quantitation of specimens that show M-spikes by electrophoresis
Detecting urine monoclonal proteins and identification of specimens that need urine protein electrophoresis
Special Instructions
Method Name
KTLCU, LTLCU: Nephelometry
Reporting Name
Immunoglobulin Total Light Chains,USpecimen Type
UrineOrdering Guidance
If serum is being submitted on the same patient for FLCS / Immunoglobulin Free Light Chains, Serum; that test should be ordered under a different order number.
Specimen Required
Submit only 1 of the following specimens:
Supplies:Â Sarstedt Aliquot Tube, 5 mL (T914)
Specimen Type: Random urine
Collection Container/Tube: Clean, plastic urine collection container
Submission Container/Tube: Plastic, 5-mL tube
Specimen Volume: 1 mL
Collection Instructions:
1. Collect a random urine specimen.
2. Refrigerate after collection and send refrigerate.
Specimen Type: 24-Hour urine
Container/Tube: Plastic, 5-mL tube
Specimen Volume: 1 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. No additive needed for preservation.
3. Urine may be kept ambient during the collection period but should be refrigerated within 4 hours of collection completion.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 20 days | ||
| Ambient | 72 hours |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
KAPPA TOTAL LIGHT CHAIN
<0.9 mg/dL
LAMBDA TOTAL LIGHT CHAIN
<0.7 mg/dL
KAPPA/LAMBDA RATIO
0.7-6.2
Interpretation
A kappa/lambda (K/L) ratio greater than 6.2 suggests the presence of monoclonal kappa light chains.
A K/L ratio less than 0.7 suggests the presence of monoclonal lambda light chains.
In 24-hour specimens, a greater than 90% increase in concentration suggests progression or relapse; a greater than 90% decrease suggests treatment response.
Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders.
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 3 daysSpecimen Retention Time
14 daysTest Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83883 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TLCU | Immunoglobulin Total Light Chains,U | 44792-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| KLTRU | Kappa/Lambda TLC Ratio, U | 33559-6 |
| KTLCU | Kappa Total Light Chain, U | 27365-6 |
| LTLCU | Lambda Total Light Chain, U | 27394-6 |
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| KTLCU | Kappa Total Light Chain, U | No | Yes |
| LTLCU | Lambda Total Light Chain, U | No | Yes |
| KLTRU | Kappa/Lambda TLC Ratio, U | No | Yes |