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Test Code LAB0288654 Nortriptyline, Serum

Additional Codes

 

Mayo Test ID
NOTRP

 

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring nortriptyline concentration during therapy

 

Evaluating potential nortriptyline toxicity

 

May aid in evaluating patient compliance

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Nortriptyline, S

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose (minimum 12 hours after last dose).

2. Centrifuge and aliquot serum into a plastic vial. Serum must be separated from cells within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Therapeutic concentration: 70-170 ng/mL

Note: Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

Interpretation

Most individuals display optimal response to nortriptyline with serum levels of 70 to 170 ng/mL. Risk of toxicity is increased with nortriptyline levels above 500 ng/mL.

 

Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation.

 

Therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose).

Day(s) Performed

Tuesday, Thursday, Sunday

Report Available

3 to 5 days

Specimen Retention Time

14 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NOTRP Nortriptyline, S 3872-9

 

Result ID Test Result Name Result LOINC Value
37119 Nortriptyline, S 3872-9

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.