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HelpTest Code LAB0263467 Methylmalonic Acid, Quantitative, Serum
Additional Codes
| Mayo Test ID |
|---|
| MMAS |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Evaluating children with signs and symptoms of methylmalonic acidemia using serum specimens
Evaluating individuals with signs and symptoms associated with a variety of causes of vitamin B12 (cobalamin) deficiency
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Methylmalonic Acid, QN, SSpecimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume:1.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 48 days | |
| Ambient | 48 days | ||
| Frozen | 48 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
≤0.40 nmol/mL
Interpretation
In pediatric patients, markedly elevated methylmalonic acid values indicate a probable diagnosis of methylmalonic acidemia. Additional confirmatory testing must be performed.
In adults, moderately elevated values indicate a likely vitamin B12 (cobalamin) deficiency.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysSpecimen Retention Time
1 weekTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83921
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MMAS | Methylmalonic Acid, QN, S | 13964-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 80289 | Methylmalonic Acid, QN, S | 13964-2 |
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Benign Hematology Test Request (T755)