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HelpTest Code LAB0263459 Methylmalonic Acid, Quantitative, Urine
Additional Codes
| Mayo Test ID |
|---|
| MMAU |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Evaluating children with signs and symptoms of methylmalonic acidemia using urine specimens
Evaluating individuals with signs and symptoms associated with a variety of causes of vitamin B12 (cobalamin) deficiency
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Methylmalonic Acid, QN, USpecimen Type
UrineSpecimen Required
Patient Preparation: Overnight fast required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 4 mL
Collection Instructions: Collect second-voided specimen after an overnight fast.
Specimen Minimum Volume
1.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 28 days | |
| Refrigerated | 28 days | ||
| Ambient | 21 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
<3.60 mmol/mol creatinine
Interpretation
In pediatric patients, markedly elevated methylmalonic acid values indicate a probable diagnosis of methylmalonic acidemia. Additional confirmatory testing must be performed.
In adults, moderately elevated values indicate a likely vitamin B12 (cobalamin) deficiency.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysSpecimen Retention Time
1 weekTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83921
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MMAU | Methylmalonic Acid, QN, U | 25116-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 80290 | Methylmalonic Acid, QN, U | 25116-5 |
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Biochemical Genetics Test Request (T798)
-Benign Hematology Test Request (T755)