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Test Code LAB0255349 Pancreatic Polypeptide, Plasma

Additional Codes

Mayo Test ID
HPP

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detecting pancreatic endocrine tumors

 

Assessing vagal nerve function after meal or sham feeding

Method Name

Radioimmunoassay (RIA)

Reporting Name

Pancreatic Polypeptide, P

Specimen Type

Plasma EDTA
CentraCare Laboratory Services Note:

Freeze plasma within 1 hour of collection and submit frozen.


Ordering Guidance


This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.



Necessary Information


Patient's age must be provided.



Specimen Required


Patient Preparation:

1. Fasting: 8 hours, required

2. The patient should not have recently received radioisotopes, either therapeutically or diagnostically, due to potential assay interference. See Ordering Guidance.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL Plasma

Collection Instructions:

1. Place specimen on wet ice and keep cold at all times following collection.

2. Centrifuge (refrigerated centrifuge is not required) and aliquot plasma into a plastic vial. Freeze immediately.


Specimen Minimum Volume

Plasma: 0.35 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen (preferred) 90 days
  Refrigerated  14 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK

Reference Values

0-19 years: Not established

20-29 years: <228 pg/mL

30-39 years: <249 pg/mL

40-49 years: <270 pg/mL

50-59 years: <291 pg/mL

60-69 years: <312 pg/mL

70-79 years: <332 pg/mL

≥80 years: Not established

Interpretation

High levels of pancreatic polypeptide may be seen in pancreatic endocrine tumors, diabetes, and a nonfasting state. Markedly elevated levels may be seen in some pancreatic exocrine tumors.

 

A normal response to sham feeding consists of a rapid pancreatic polypeptide rise over baseline followed by a return to baseline. With vagal damage, no increase over baseline is seen.

Day(s) Performed

Tuesday

Report Available

4 to 10 days

Specimen Retention Time

2 weeks

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83519

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HPP Pancreatic Polypeptide, P 2721-9

 

Result ID Test Result Name Result LOINC Value
8014 Pancreatic Polypeptide, P 2721-9

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.