Test Code LAB0255349 Pancreatic Polypeptide, Plasma
Additional Codes
| Mayo Test ID |
|---|
| HPP |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Detecting pancreatic endocrine tumors
Assessing vagal nerve function after meal or sham feeding
Method Name
Radioimmunoassay (RIA)
Reporting Name
Pancreatic Polypeptide, PSpecimen Type
Plasma EDTAFreeze plasma within 1 hour of collection and submit frozen.
Ordering Guidance
This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.
Necessary Information
Patient's age must be provided.
Specimen Required
Patient Preparation:
1. Fasting: 8 hours, required
2. The patient should not have recently received radioisotopes, either therapeutically or diagnostically, due to potential assay interference. See Ordering Guidance.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 3 mL Plasma
Collection Instructions:
1. Place specimen on wet ice and keep cold at all times following collection.
2. Centrifuge (refrigerated centrifuge is not required) and aliquot plasma into a plastic vial. Freeze immediately.
Specimen Minimum Volume
Plasma: 0.35 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma EDTA | Frozen (preferred) | 90 days |
| Refrigerated | 14 days | |
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
0-19 years: Not established
20-29 years: <228 pg/mL
30-39 years: <249 pg/mL
40-49 years: <270 pg/mL
50-59 years: <291 pg/mL
60-69 years: <312 pg/mL
70-79 years: <332 pg/mL
≥80 years: Not established
Interpretation
High levels of pancreatic polypeptide may be seen in pancreatic endocrine tumors, diabetes, and a nonfasting state. Markedly elevated levels may be seen in some pancreatic exocrine tumors.
A normal response to sham feeding consists of a rapid pancreatic polypeptide rise over baseline followed by a return to baseline. With vagal damage, no increase over baseline is seen.
Day(s) Performed
Tuesday
Report Available
4 to 10 daysSpecimen Retention Time
2 weeksTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83519
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HPP | Pancreatic Polypeptide, P | 2721-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8014 | Pancreatic Polypeptide, P | 2721-9 |
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.