Sign in →

Test Code LAB0252577 Topiramate, Serum

Additional Codes

Mayo Test ID
TOPI

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum concentrations of topiramate

 

Assessing compliance

 

Assessing potential toxicity

Reporting Name

Topiramate, S

Specimen Type

Serum Red


Specimen Required


Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Centrifuge and aliquot serum into plastic vial; within 2 hours of collection.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Anticonvulsant: 5.0-20.0 mcg/mL

Interpretation

Most individuals display optimal response to topiramate with serum levels 5.0 to 20.0 mcg/mL when used to control seizures. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation.

 

Therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose).

 

Toxic levels have not been well established.

Day(s) Performed

Monday through Friday

Report Available

1 to 2 days

Specimen Retention Time

14 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80201

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TOPI Topiramate, S 17713-9

 

Result ID Test Result Name Result LOINC Value
81546 Topiramate, S 17713-9

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)