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Test Code LAB0232777 Immunoglobulin D (IgD), Serum

Additional Codes

Mayo Test ID
IGD

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Providing information on the humoral immune status

 

Identifying an IgD monoclonal gammopathy

Method Name

Turbidimetry

Reporting Name

Immunoglobulin D (IgD), S

Specimen Type

Serum


Ordering Guidance


To distinguish between polyclonal and monoclonal IgD, order PEISO / Protein Electrophoresis and Isotype, Serum.



Specimen Required


Supplies: Sarstedt 5 mL Aliquot Tube (T914)

Patient Preparation: Fasting preferred but not required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  21 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK
Heat-activated specimen Reject

Reference Values

≤10 mg/dL

Interpretation

The physiologic significance of serum IgD concentration is unclear and in many normal persons serum IgD is undetectable.

 

Increased concentrations may be due to polyclonal (reactive) or monoclonal plasma cell proliferative processes.

 

A monoclonal IgD protein is present in 1% of patients with myeloma. Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable monoclonal protein on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Specimen Retention Time

14 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82784

LOINC Code Information

Test ID Test Order Name Order LOINC Value
IGD Immunoglobulin D (IgD), S 2460-4

 

Result ID Test Result Name Result LOINC Value
IGD Immunoglobulin D (IgD), S 2460-4