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Test Code LAB0232439 Measles (Rubeola) Antibodies, IgG, Serum

Additional Codes

 

Mayo Test ID
ROPG

 

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Determining immune status of individuals to the measles virus

 

Documenting previous infection with measles virus in an individual without a previous record of immunization to measles virus

Method Name

Multiplex Flow Immunoassay (MFI)

Reporting Name

Measles (Rubeola) Ab, IgG, S

Specimen Type

Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Instructions: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-inactivated specimen Reject

Reference Values

Vaccinated: positive (≥1.1 AI)

Unvaccinated: negative (≤0.8 AI)

Reference values apply to all ages.

Interpretation

The reported antibody index (AI) value is for reference only. This is a qualitative test, and the numeric value of the AI is not indicative of the amount of antibody present. AI values above the manufacturer recommended cutoff for this assay indicate that specific antibodies were detected, suggesting prior exposure or vaccination.

 

Positive: AI value of 1.1 or higher

The presence of detectable IgG-class antibodies indicates prior exposure to the measles virus through infection or immunization. Individuals testing positive are considered immune to measles infection.

 

Equivocal: AI value 0.9-1.0

Submit an additional sample for testing in 10 to 14 days to demonstrate IgG seroconversion if recently vaccinated or otherwise clinically indicated.

 

Negative: AI value of 0.8 or lower

The absence of detectable IgG-class antibodies suggests the lack of a specific immune response to immunization or no prior exposure to the measles virus.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days

Specimen Retention Time

14 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86765

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ROPG Measles (Rubeola) Ab, IgG, S 77310-1

 

Result ID Test Result Name Result LOINC Value
ROG Measles (Rubeola) Ab, IgG, S 35275-7
DEXG3 Measles IgG Antibody Index 5244-9

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.