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Test Code LAB0220728 Coccidioides Antibody, Complement Fixation and Immunodiffusion, Spinal Fluid

Additional Codes

Mayo Test ID
CCOC

Reporting Name

Coccidioides Ab, CompF/ImmDiff, CSF

Useful For

Diagnosing coccidioidomycosis using spinal fluid specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

CSF


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 2 mL

Collection Instructions: Submit specimen from collection vial 2.


Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

COMPLEMENT FIXATION

Negative

If positive, results are titered.

 

IMMUNODIFFUSION

Negative

Results are reported as positive, negative, or equivocal.

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86635 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CCOC Coccidioides Ab, CompF/ImmDiff, CSF 88745-5

 

Result ID Test Result Name Result LOINC Value
81542 Coccidioides Ab, CompF, CSF 13917-0
21002 Coccidioides, IgG, ImmDiff, CSF 94662-4
21001 Coccidioides, IgM, ImmDiff, CSF 94663-2

Interpretation

Complement Fixation:

IgG antibody is detected by complement fixation (CF) testing. Any CF titer in cerebrospinal fluid (CSF) should be considered significant. A positive complement fixation test in un-concentrated CSF is diagnostic of meningitis.

 

Immunodiffusion:

IgM and IgG precipitins are rarely found in CSF. However, when present, they are diagnostic of meningitis (100% specific). Since the immunodiffusion test is 100% specific, it is helpful in interpreting CF results.

Report Available

3 to 6 days

Specimen Retention Time

14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK

Method Name

Complement Fixation (CF) / Immunodiffusion (ID)

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Testing Algorithm

For more information see Meningitis/Encephalitis Panel Algorithm.