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Test Code LAB0213470 Ceruloplasmin, Serum

Additional Codes

 

Mayo Test ID
CERS

 


Specimen Required


Patient Preparation: Patient should be fasting: 4 hours preferred, nonfasting acceptable

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Useful For

Investigation of patients with possible Wilson disease

Testing Algorithm

For information see Wilson Disease Testing Algorithm.

Special Instructions

Method Name

Nephelometric Assay

Reporting Name

Ceruloplasmin, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Males:

0-8 weeks: 7.4-23.7 mg/dL

9 weeks-5 months: 13.5-32.9 mg/dL

6-11 months: 13.7-38.9 mg/dL

12 months-7 years: 21.7-43.3 mg/dL

8-13 years: 20.5-40.2 mg/dL

14-17 years: 17.0-34.8 mg/dL

≥18 years: 19.0-31.0 mg/dL

 

Females:

0-8 weeks: 7.4-23.7 mg/dL

9 weeks-5 months: 13.5-32.9 mg/dL

6-11 months: 13.7-38.9 mg/dL

12 months-7 years: 21.7-43.3 mg/dL

8-13 years: 20.5-40.2 mg/dL

14-17 years: 20.8-43.2 mg/dL

≥18 years: 20.0-51.0 mg/dL

Interpretation

Low concentrations of ceruloplasmin are consistent with Wilson disease and warrant further investigation according to the recommended algorithm; see Wilson Disease Testing Algorithm.

 

Ceruloplasmin is a positive acute-phase reactant. Increases in serum ceruloplasmin have been reported during pregnancy, in women taking oral contraceptives, in hepatitis, pneumonia, tuberculosis, rheumatoid arthritis, myocardial infarction, various forms of anemia, and many obscure neurological disorders.

Day(s) Performed

Monday through Sunday

Report Available

1 to 7 days

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82390

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CERS Ceruloplasmin, S 2064-4

 

Result ID Test Result Name Result LOINC Value
CERS Ceruloplasmin, S 2064-4

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Benign Hematology Test Request (T755)

-General Request (T239)

-Gastroenterology and Hepatology Test Request (T728)

-Biochemical Genetics Test Request (T798)