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Test Code LAB0002214 Histoplasma and Blastomyces Antigen, Enzyme Immunoassay, Serum

Additional Codes

Mayo Test ID
HIBAG


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Diagnosing Histoplasma capsulatum or Blastomyces dermatitidis infection, without differentiation between the organisms, using serum specimens

 

Monitor antigen levels following initiation of antifungal treatment

Method Name

Enzyme Immunoassay (EIA)

Reporting Name

Histoplasma/Blastomyces Ag, EIA, S

Specimen Type

Serum

Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-inactivated specimen Reject

Reference Values

Histoplasma/Blastomyces Antigen Result:

Not detected

 

Histoplasma/Blastomyces Antigen Value:

Not detected

Detected: <1.5 ng/mL

Detected: 1.5-25.0 ng/mL

Detected: >25.0 ng/mL

 

Reference values apply to all ages.

Interpretation

Not detected: No antigen from Histoplasma or Blastomyces detected. False-negative results may occur depending on the extent of disease or site of infection. Repeat testing on a new specimen if clinically indicated.

 

Detected: Antigen from Histoplasma or Blastomyces (unable to differentiate) was detected, below the limit of quantification (<1.5 ng/mL). Definitive identification requires additional testing, including serology, culture, histopathology, and/or molecular methods. Results should be correlated with clinical presentation and exposure history.

 

Detected: Antigen from Histoplasma or Blastomyces (unable to differentiate) detected. Definitive identification requires additional testing, including serology, culture, histopathology, and/or molecular methods.  Results should be correlated with clinical presentation and exposure history.

 

Detected: Antigen from Histoplasma or Blastomyces (unable to differentiate) detected, above the limit of quantification (>25.0 ng/mL). Definitive identification requires additional testing, including serology, culture, histopathology, and/or molecular methods.  Results should be correlated with clinical presentation and exposure history..

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87449

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIBAG Histoplasma/Blastomyces Ag, EIA, S 101587-4

 

Result ID Test Result Name Result LOINC Value
619492 Histoplasma/Blastomyces Ag Result 101588-2
619493 Histoplasma/Blastomyces Ag Value 101589-0

Forms

If not ordering electronically, complete, print, and send a Kidney Transplant Test Request with the specimen.