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Test Code ZNCRU Zinc/Creatinine Ratio, Random, Urine

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Identifying the cause of abnormal serum zinc concentrations using a random urine specimen

Method Name

ZNCR: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

CDCR: Enzymatic Colorimetric Assay

Reporting Name

Zinc/Creat Ratio, Random, U

Specimen Type

Urine


Specimen Required


Patient Preparation:

High concentrations of barium are known to interfere with most metals tests. If barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert

Submission Container/Tube: Plastic urine tube (T068) or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen.

2. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.


Specimen Minimum Volume

0.7 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Reference Values

0-17 years: not established

≥18 years: 89-910 mcg/g Creatinine

Interpretation

Fecal excretion of zinc is the dominant route of elimination. Renal excretion is a minor, secondary elimination pathway. Normal daily excretion of zinc in the urine is in the range of 89 to 910 mcg/g creatinine.

 

High urine zinc associated with low serum zinc may be caused by hepatic cirrhosis, neoplastic disease, or increased catabolism.

 

High urine zinc with normal or elevated serum zinc indicates a large dietary source, usually in the form of high-dose vitamins.

 

Low urine zinc with low serum zinc may be caused by dietary deficiency or loss through exudation common in burn patients and those with gastrointestinal losses.

Day(s) and Time(s) Performed

Tuesday, Thursday; 8 a.m.

Analytic Time

1 day

Specimen Retention Time

14 days

Test Classification

See Individual Test IDs

CPT Code Information

84630 Zinc Concentration

82570 Creatinine Concentration

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ZNCRU Zinc/Creat Ratio, Random, U 13473-4

 

Result ID Test Result Name Result LOINC Value
CDCR Creatinine Conc 2161-8
32876 Zinc/Creat Ratio, U 13473-4

Profile Information

Test ID Reporting Name Available Separately Always Performed
ZNCR Zinc/Creat Ratio, U No Yes
CDCR Creatinine Conc No Yes