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Test Code MSMRT Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report

Useful For

Risk stratification of patients with multiple myeloma, which can assist in determining treatment and management decisions


Risk stratification of patients with newly diagnosed multiple myeloma

Reflex Tests

Test ID Reporting Name Available Separately Always Performed

Testing Algorithm

Based on the flow cytometric analysis and presence of greater than or equal to 0.1% monotypic plasma cells, the MPCPD / mSMART, Plasma Cell Proliferative Disorder (PCPD), FISH test will be reflexed and performed at an additional charge.


See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.

Method Name

Flow Cytometry/DNA Content/Cell Cycle Analysis

Reporting Name

mSMART Algorithmic Testing, BM

Specimen Type

Bone Marrow

Advisory Information

This test should be ordered at diagnosis of Multiple Myeloma and when the client wants MPCPD / mSMART, Plasma Cell Proliferative Disorder (PCPD), FISH to be reflexed based on the Laboratory Screening Tests for Suspected Multiple Myeloma algorithm.

Necessary Information

1. Include patient's disease state (untreated, treated, monoclonal gammopathy of undetermined significance, stable).

2. Indicate if patient is on anti-CD38 therapy.

Specimen Required

Specimen Type: Redirected bone marrow

Preferred: Yellow top (ACD)

Acceptable: EDTA or heparin

Specimen Volume: 4 mL

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Bone Marrow Ambient (preferred) 72 hours
  Refrigerated  72 hours

Reject Due To


Mild OK; Gross reject






Fully clotted or frozen specimen

Reference Values

Plasma Cell Clonality:

Normal bone marrow

No monotypic clonal plasma cells detected

DNA Index:

Normal polytypic plasma cells

DNA index (G0/G1 cells): Diploid 0.95-1.05


An interpretive report is provided. Patients are classified as high risk, intermediate, or standard risk.

Day(s) and Time(s) Performed

Specimens are processed Monday through Sunday and reported Monday through Friday 8 a.m.-5 p.m.

Analytic Time

1 day (MSMRT only) 11 days (with MPCPD)

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

88182-Flow cytometry, cell cycle or DNA analysis

88184-Flow cytometry; first cell surface, cytoplasmic or nuclear marker

88185 x 5-Flow cytometry; additional cell surface, cytoplasmic or nuclear marker (each)

88187-Flow cytometry interpretation, 2 to 8 Markers

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MSMRT mSMART Algorithmic Testing, BM In Process


Result ID Test Result Name Result LOINC Value
CK056 Monotypic Plasma Cells: In Process
CK057 Monotypic PC per Total Events In Process
CK058 Monotypic Plasma Cells S-phase In Process
CK059 Monotypic Plasma Cells DNA Index In Process
CK060 Monotypic Plasma Cells DNA Ploidy In Process
CK061 Polytypic PC per Total Events In Process
CK062 Polytypic PC per All Plasma Cells In Process
CK134 Final Diagnosis In Process


If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.