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Test Code DIRM D-Dimer, Plasma

Useful For

Diagnosis of intravascular coagulation and fibrinolysis (ICF), also known as disseminated intravascular coagulation (DIC), especially when combined with clinical information and other laboratory test data (eg, platelet count, assays of clottable fibrinogen and soluble fibrin monomer complex, and clotting time assays-prothrombin time and activated partial thromboplastin time)


Excluding the diagnosis of acute pulmonary embolism or deep vein thrombosis, particularly when results of a sensitive D-dimer assay are combined with clinical information, including pretest disease probability.

Method Name

Latex Immunoassay (LIA)

Reporting Name

D-Dimer, P

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Cit Frozen 14 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject






Reference Values

Only orderable as part of a coagulation consultation. For more information see 1 of the following:

BDIAC / Bleeding Diathesis Profile, Comprehensive



≤250 ng/ml D-Dimer Units (DDU)

≤0.5 mcg/mL Fibrinogen Equivalent Units (FEU)


D-dimer values ≤250 ng/mL DDU (≤0.50 mcg/mL FEU) are normal. Within the reportable normal range (110-250 ng/mL DDU; 0.22-0.50 mcg/mL FEU), measured values may reflect the activation state of the procoagulant and fibrinolytic systems, but the clinical utility of such quantitation is not established.


A normal D-dimer result (≤250 ng/mL DDU; ≤0.50 mcg/mL FEU) has a negative predictive value of approximately 95% for the exclusion of acute pulmonary embolism (PE) or deep vein thrombosis when there is low or moderate pretest PE probability.


Increased D-dimer values are abnormal but do not indicate a specific disease state. D-dimer values may be increased as a result of:

-Clinical or subclinical disseminated intravascular coagulopathy (DIC)/intravascular coagulation and fibrinolysis (ICF).

-Other conditions associated with increased activation of the procoagulant and fibrinolytic mechanisms such as recent surgery, active or recent bleeding, hematomas, trauma, or thromboembolism.

-Association with pregnancy, liver disease, inflammation, malignancy or hypercoagulable (procoagulant) states.


The degree of D-dimer increase does not definitely correlate with the clinical severity of associated disease states.

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

1 hour

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
DIRM D-Dimer, P 55398-2


Result ID Test Result Name Result LOINC Value
DDMDR Fibrinogen Equivalent Units (FEU) 48067-3
DDIME D-Dimer Units (DDU) 48058-2