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Test Code C6FX C6 Complement, Functional, Serum

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Diagnosis of C6 deficiency

 

Investigation of a patient with an undetectable total complement (CH50) level

Method Name

Automated Liposome Lysis Assay

Reporting Name

C6 Complement, Functional, S

Specimen Type

Serum Red


Advisory Information


The total complement (CH50) assay (COM / Complement, Total, Serum) should be used as a screen for suspected complement deficiencies before ordering individual complement component assays. A deficiency of an individual component of the complement cascade will result in an undetectable total complement level.

Specimen Required


Patient Preparation: Fasting preferred

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Red top

Submission Container/Tube: Plastic, 5 mL tube

Specimen Volume: 1 mL                   

Collection Instructions:

1. Immediately after specimen collection, place the tube on wet ice.

2. Centrifuge and separate serum from clot.

3. Immediately freeze specimen.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Frozen 14 days

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross OK

Other

Serum gel tube

Reference Values

32-57 U/mL

Interpretation

Low levels of complement may be due to inherited deficiencies, acquired  deficiencies, or due to complement consumption (eg, as a consequence of infectious or autoimmune processes). Absent C6 levels in the presence of normal C3 and C4 values are consistent with a C6 deficiency. Absent C6 levels in the presence of low C3 and C4 values suggests complement consumption.

 

Normal results indicate both normal C6 protein levels and normal functional activity.

Day(s) and Time(s) Performed

Monday through Saturday; Continuous with a 3 p.m. cutoff

Analytic Time

Same day/1 day

Specimen Retention Time

14 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86161

LOINC Code Information

Test ID Test Order Name Order LOINC Value
C6FX C6 Complement, Functional, S 60459-5

 

Result ID Test Result Name Result LOINC Value
C6FX C6 Complement, Functional, S 60459-5