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Test Code 6MAMM 6-Monoacetylmorphine (6-MAM), Confirmation, Meconium

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detection of in utero drug exposure up to 5 months before birth

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

6-MAM Confirmation, M

Specimen Type

Meconium


Advisory Information


For chain-of-custody testing, order MAMMX / 6-Monoacetylmorphine (6-MAM) Confirmation, Chain of Custody, Meconium.



Specimen Required


Supplies: Stool container, Small (Random), 4 oz (T288)

Container/Tube: Stool container (T288)

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions:

1. Collect entire random meconium specimen.

2. Send specimen frozen. When refrigerated, a significant percentage of 6-MAM will convert to morphine in less than 24 hours.


Specimen Minimum Volume

0.3 g (approximately 1/4 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time
Meconium Frozen 14 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Grossly bloody reject, Pink OK; stool, diapers

Reference Values

Negative

Positives are reported with a quantitative LC-MS/MS result.

Cutoff concentration:

6-MAM by LC-MS/MS: 5 ng/g

Interpretation

The presence of 6-monoacetylmorphine (6-MAM) in meconium is definitive for heroin use by the mother. However, the absence of 6-MAM does not rule-out heroin use, because of its short half-life.

Day(s) and Time(s) Performed

Monday through Sunday; Varies

Analytic Time

2 days

Specimen Retention Time

2 weeks

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80356

G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
6MAMM 6-MAM Confirmation, M 29345-6

 

Result ID Test Result Name Result LOINC Value
31874 6-Monoacetylmorphine 29345-6
31875 Interpretation 69050-3