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Test Code 0298331 N-terminal Telopeptide (NTx), Serum

Additional Codes

 

Mayo Test ID
SNTX

 


Specimen Required


Patient Preparation: A morning collection from fasting patients is preferred due to diurnal variation of markers and food effects.

 

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic screw-top aliquot tube

Specimen Volume: 0.5 mL

Collection Instructions: A morning collection from fasting patients is preferred. If not possible, collect the baseline and subsequent specimens under the same circumstances (eg, at same time of day).


Useful For

Monitoring effectiveness of antiresorptive therapy in patients treated for osteoporosis or other metabolic bone disorders

 

As an adjunct in the diagnosis of medical conditions associated with increased bone turnover

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

NTX-Telopeptide, S

Specimen Type

Serum

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 28 days
  Refrigerated  24 hours

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild Ok; Gross reject

Other

Reference Values

All units are reported in nmol Bone Collagen Equivalents (BCE)

Adult (≥18 years of age)

 

Males:

5.4-24.2 nmol BCE

 

Females:

Premenopausal: 6.2-19.0 nmol BCE

The target value for postmenopausal adult females undergoing treatment for osteoporosis is the same as the premenopausal reference interval.

Interpretation

Elevated levels of N-terminal telopeptide (NTx) indicate increased bone resorption.

 

A 30% or greater reduction in this resorption marker 3 to 6 months after initiation of therapy indicates a probably adequate therapeutic response.

 

A common target of antiresorptive therapy in the treatment of postmenopausal osteoporosis is to achieve bone markers concentrations within the premenopausal reference range.

Day(s) and Time(s) Performed

Tuesday, Thursday; 10 a.m.

Analytic Time

1 day

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82523

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SNTX NTX-Telopeptide, S 21215-9

 

Result ID Test Result Name Result LOINC Value
65558 NTX-Telopeptide, S 21215-9