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Test Code 0289579 6-Monoacetylmorphine (6-MAM) Confirmation, Urine

Additional Codes


Mayo Test ID


Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Determination of heroin use

Method Name

Gas Chromatography-Mass Spectrometry (GC-MS)

Reporting Name

6-MAM Confirmation, U

Specimen Type


Advisory Information

1. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Urine.

2. For chain-of-custody testing, order 6MAMX / 6-Monoacetylmorphine (6-MAM), Chain of Custody, Urine.

Specimen Required

Supplies: Urine Container, 60 mL (T313)

Collection Container/Tube: Plastic, 60-mL urine container (T313)

Specimen Volume: 20 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Additional Information:

1. No specimen substitutions.

2. No STATS are accepted for this procedure.

Specimen Minimum Volume

2.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To


Mild OK; Gross OK




Mild OK; Gross OK



Reference Values


Cutoff concentrations:


<5 ng/mL


The presence of 6-monoacetylmorphine (6-MAM) in urine is definitive for recent heroin use. However, the absence of 6-MAM does not rule-out heroin use because of its short half-life. 6-MAM is typically only detectable within 24 hours of heroin use. 6-MAM is further metabolized into morphine, which may be detected 1 to 2 days after 6-MAM is no longer measurable. Morphine will typically be found in a specimen containing 6-MAM.(2,3)

Day(s) and Time(s) Performed

Monday, Wednesday

Analytic Time

2 days

Specimen Retention Time

2 weeks

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
6MAMU 6-MAM Confirmation, U 19593-3


Result ID Test Result Name Result LOINC Value
30983 6-Monoacetylmorphine by GC/MS 19593-3
29898 6-MAM Interpretation 69050-3
29899 Chain of Custody 77202-0