Sign in →

Test Code 0253260 Haloperidol, Serum

Additional Codes

Mayo Test ID
HALO

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Optimizing dosage

 

Monitoring compliance

 

Assessing toxicity

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Haloperidol, S

Specimen Type

Serum Red


Specimen Required


Container/Tube: Red top

Specimen Volume: 1 mL


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

Serum gel tube

Reference Values

HALOPERIDOL

5-16 ng/mL

 

REDUCED HALOPERIDOL

10-80 ng/mL

Interpretation

Studies show a strong relationship between dose and serum concentration (4); however, there is a modest relationship of clinical response or risk of developing long-term side effects to either dose or serum concentration.

 

A therapeutic window exists for haloperidol; patients who respond at serum concentrations between 5 to 16 ng/mL show no additional improvement at concentrations >16 to 20 ng/mL.(3,5) Some patients may respond at concentrations <5 ng/mL, and others may require concentrations significantly >20 ng/mL before an adequate response is attained.

 

Because of such inter-individual variation, the serum concentration should only be used as 1 factor in determining the appropriate dose and must be interpreted in conjunction with the clinical status.

 

Although the metabolite, reduced haloperidol, has minimal pharmacologic activity, evidence has been presented suggesting that an elevated ratio of reduced haloperidol-to-haloperidol (ie, >5) is predictive of a poor clinical response.(3,6) A reduced haloperidol-to-haloperidol ratio <0.5 indicates noncompliance; the metabolite does not accumulate except during steady-state conditions.

Day(s) and Time(s) Performed

Tuesday, Thursday; 4 p.m.

Analytic Time

2 days

Specimen Retention Time

14 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80173

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HALO Haloperidol, S 87550-0

 

Result ID Test Result Name Result LOINC Value
80339 Haloperidol, S 3669-9
169 Reduced Haloperidol 38364-6