Sign in →

Test Code 0231654 Ganglioside Antibody Panel, Serum

Additional Codes

 

Mayo Test ID
GM1B

 

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Supporting the diagnosis of an autoimmune neuropathy

Testing Algorithm

Screening tests are performed for IgG and IgM antibodies to GM1 and GD1b. If positive, the appropriate titer will be performed.

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Ganglioside Ab Panel, S

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross reject

Other

NA

Reference Values

Profile Information:

IGG_M: Negative

IGM_M: Negative

IGG_A: Negative

IGM_A: Negative

IGG_D: Negative

IGM_D: Negative

 

Reflex Information:

IGMTS: <1:2000

IMMTS: <1:4000

IGATS: <1:16000

IMATS: <1:8000

IGDTS: <1:2000

IMDTS: <1:2000

Interpretation

High titers (>1:8,000) favor the diagnosis of multifocal motor neuropathy (MMN) and multifocal acquired demyelinating sensory and motor (MADSAM) over motor neuron disease. About 30% to 50% of patients with these clinical syndromes or the pure motor variant of chronic inflammatory demyelinating polyneuropathy have ganglioside autoantibodies. High-antibody titers appear to be a specific, but not sensitive, marker of those related disorders.

Day(s) and Time(s) Performed

Tuesday, Thursday; 12 p.m.

Analytic Time

5 days

Specimen Retention Time

28 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83516 x 6

83520 x 6 (if applicable)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GM1B Ganglioside Ab Panel, S 82455-7

 

Result ID Test Result Name Result LOINC Value
4414 IgG Asialo. GM1 46969-2
4416 IgG Disialo. GD1b 13662-2
4412 IgG Monos. GM1 43240-1
4415 IgM Asialo. GM1 43179-1
4417 IgM Disialo. GD1b 13661-4
4413 IgM Monos. GM1 43241-9

Profile Information

Test ID Reporting Name Available Separately Always Performed
IGG_M IgG Monos. GM1 No Yes
IGM_M IgM Monos. GM1 No Yes
IGG_A IgG Asialo. GM1 No Yes
IGM_A IgM Asialo. GM1 No Yes
IGG_D IgG Disialo. GD1b No Yes
IGM_D IgM Disialo. GD1b No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IGMTS IgG Monos GM1 Titer, S No No
IMMTS IgM Monos GM1 Titer, S No No
IGATS IgG Asialo GM1 Titer, S No No
IMATS IgM Asialo GM1 Titer, S No No
IGDTS IgG Disialo GD1b Titer, S No No
IMDTS IgM Disialo GD1b Titer, S No No

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.