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Test Code 0231654 Ganglioside Antibody Panel, Serum

Additional Codes

 

Mayo Test ID
GM1B

 

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Supporting diagnosis of neurological diseases-primarily motor neuron disease and motor neuropathies

Method Name

Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Ganglioside Ab Panel, S

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 14 days
  Refrigerated  14 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross OK

Other

NA

Reference Values

99% of Normals Fall at or Below This Titer

IgG monosialo GM1

1:500

IgM monosialo GM1

1:1,000

IgG asialo GM1

1:4,000

IgM asialo GM1

1:4,000

IgG disialo GD1b

1:1,000

IgM disialo GD1b

1:1,000

 

Borderline Ranges

IgG monosialo GM1

=1:1,000

IgM monosialo GM1

=1:2,000

IgG asialo GM1

=1:8,000

IgM asialo GM1

No borderline range (normal: ≤4,000)

IgG disialo GD1b

No borderline range (normal: ≤1,000)

IgM disialo GD1b

No borderline range (normal: ≤1,000)

 

Abnormal Results

IgG monosialo GM1

>1:1,000

IgM monosialo GM1

>1:2,000

IgG asialo GM1

>1:8,000

IgM asialo GM1

>1:4,000

IgG disialo GD1b

>1:1,000

IgM disialo GD1b

>1:1,000

Interpretation

High titers (>1:2,000) have been found only in patients with multifocal motor neuropathy and not with motor neuron disease. About 30% to 50% of patients with these clinical syndromes or the pure motor variant of chronic inflammatory demyelinating polyneuropathy have increased antibody titers. Increased antibody titers, therefore, appear to be a specific but not sensitive marker of those related disorders.

 

Borderline elevation of titers against ganglioside epitopes may be seen in patients with motor neuron disease or motor neuropathy

 

For IgG and IgM antibodies directed against monosialo GM1 and disialo GD1b, 99% of 182 age- and sex-stratified normal individuals had titers <1:1,000; 99% of 121 patients with well-defined motor neuron disease had titers <1:2,000; and all patients with titers >1:2,000 had motor neuropathy.

Day(s) and Time(s) Performed

Tuesday, Thursday; 3 p.m.

Analytic Time

3 days

Specimen Retention Time

Negatives - 1 week ; Positives - 6 months

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83516 x 6

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GM1B Ganglioside Ab Panel, S 82455-7

 

Result ID Test Result Name Result LOINC Value
4414 IgG Asialo. GM1 46969-2
4416 IgG Disialo. GD1b 13662-2
4412 IgG Monos. GM1 43240-1
4415 IgM Asialo. GM1 43179-1
4417 IgM Disialo. GD1b 13661-4
4413 IgM Monos. GM1 43241-9
4418 Comment 48767-8

Profile Information

Test ID Reporting Name Available Separately Always Performed
IGG_M IgG Monos. GM1 No Yes
IGM_M IgM Monos. GM1 No Yes
IGG_A IgG Asialo. GM1 No Yes
IGM_A IgM Asialo. GM1 No Yes
IGG_D IgG Disialo. GD1b No Yes
IGM_D IgM Disialo. GD1b No Yes

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.