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HelpTest Code 0214221 Neuroimmunology Antibody Follow-up, Serum
Additional Codes
| Mayo Test ID |
|---|
| PNEFS |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring patients who have previously tested positive for 1 or more antibodies within the past 5 years in a Mayo Neuroimmunology Laboratory serum evaluation
Method Name
ANN1S, ANN2S, ANN3S, AGN1S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AMPIS, GABIS, NMDIS, DPPIS, DPPTS, GL1IS, GL1TS: Indirect Immunofluorescence (IFA)
AMPCS, GABCS, NMDCS, LG1CS, CS2CS, DPPCS, GL1CS: Cell-Binding Assay (CBA)
WBN, ABLOT: Western Blot
CCPQ, CCN, GANG, VGKC, ARMO: Radioimmunoassay (RIA)
Reporting Name
Neuroimmunology Ab Follow-up, SSpecimen Type
SerumAdvisory Information
This test is only appropriate for follow-up in patients who have previously tested positive in a serum test. If patients have not previously been positive in a serum test, order 1 of the following:
-PAVAL / Paraneoplastic, Autoantibody Evaluation, Serum
-GID1 / Autoimmune Gastrointestinal Dysmotility Evaluation, Serum
-DYS1 / Autoimmune Dysautonomia Evaluation, Serum
-DMS1 / Dementia, Autoimmune Evaluation, Serum
-ENS1 / Encephalopathy, Autoimmune Evaluation, Serum
-EPS1 / Epilepsy, Autoimmune Evaluation, Serum
-MDS1 / Movement Disorder Evaluation, Serum
-MGL1 / Myasthenia Gravis (MG)/Lambert-Eaton Syndrome (LES) Evaluation
-MGA1 / Myasthenia Gravis (MG) Evaluation, Adult
-MGP1 / Myasthenia Gravis (MG) Evaluation, Pediatric
-MGT1 / Myasthenia Gravis (MG) Evaluation, Thymoma
-MGRM / Myasthenia Gravis Evaluation with MuSK Reflex, Serum
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: 13- x 75-mm plastic screw-top vial.
Specimen Volume: 4 mL
Collection Instructions: Centrifuge within 2 hours. Aliquot and ship in 13- x 75-mm plastic screw-top vial.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Reject Due To
|
Hemolysis |
Mild OK; Gross reject |
|
Lipemia |
Mild OK; Gross reject |
|
Icterus |
Mild OK; Gross reject |
|
Other |
NA |
Reference Values
|
Test ID |
Reporting Name |
Reference Value |
|
GANG |
AChR Ganglionic Neuronal Ab, S |
<0.02 |
|
AMPCS |
AMPA-R Ab CBA, S |
Negative |
|
AMPIS |
AMPA-R Ab IF Titer Assay, S |
<1:120 |
|
AMPHS |
Amphiphysin Ab, S |
<1:240 |
|
ABLOT |
Amphiphysin Western Blot, S |
Negative |
|
AGN1S |
Anti-Glial Nuclear Ab, Type 1 |
<1:240 |
|
ANN1S |
Anti-Neuronal Nuclear Ab, Type 1 |
<1:240 |
|
ANN2S |
Anti-Neuronal Nuclear Ab, Type 2 |
<1:240 |
|
ANN3S |
Anti-Neuronal Nuclear Ab, Type 3 |
<1:240 |
|
CS2CS |
CASPR2-IgG CBA, S |
Negative |
|
CRMS |
CRMP-5-IgG, S |
<1:240 |
|
GABCS |
GABA-B-R Ab CBA, S |
Negative |
|
GABIS |
GABA-B-R Ab IF Titer Assay, S |
<1:120 |
|
LG1CS |
LGI1-IgG CBA, S |
Negative |
|
VGKC |
Neuronal (V-G) K+ Channel Ab, S |
<0.02 |
|
NMDCS |
NMDA-R Ab CBA, S |
Negative |
|
NMDIS |
NMDA-R Ab IF Titer Assay, S |
<1:120 |
|
NMOTS |
NMO/AQP4 FACS Titer, S |
<1:5 |
|
CCN |
N-Type Calcium Channel Ab |
<0.03 |
|
CCPQ |
P/Q-Type Calcium Channel Ab |
<0.02 |
|
WBN |
Paraneoplastic Autoantibody WBlot,S |
Negative |
|
PCABP |
Purkinje Cell Cytoplasmic Ab Type 1 |
<1:240 |
|
PCAB2 |
Purkinje Cell Cytoplasmic Ab Type 2 |
<1:240 |
|
PCATR |
Purkinje Cell Cytoplasmic Ab Type Tr |
<1:240 |
Interpretation
Antibodies directed at onconeural proteins shared by neurons, muscle, and certain cancers are valuable serological markers of a patient's immune response to cancer. They are not found in healthy subjects and are usually accompanied by subacute neurological symptoms and signs. Several autoantibodies have a syndromic association, but no known autoantibody predicts a specific neurological syndrome. Conversely, a positive autoantibody profile has 80% to 90% predictive value for a specific cancer. It is not uncommon for more than 1 paraneoplastic autoantibody to be detected, each predictive of the same cancer.
Day(s) and Time(s) Performed
ANN1S, ANN2S, ANN3S, AGN1S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AMPIS, GABIS, NMDIS, DPPIS, DPPTS, GL1IS, GL1TS:
Monday through Friday; 11:30 a.m. and 8 p.m.
Saturday and Sunday 8 a.m.
AMPCS, GABCS, NMDCS. LG1CS, CS2CS, DPPCS, GL1CS:
Monday through Friday; 6 a.m.
WBN, , ABLOT:
Monday, Wednesday, Friday; 8 a.m.
CCPQ, CCN, GANG, VGKC:
Monday through Friday; 11 a.m. and 6 p.m.
Saturday, Sunday; 6 a.m.
ARMO:
Monday through Thursday, Saturday; 12 p.m., Saturday; 8 a.m.
Analytic Time
VariesSpecimen Retention Time
28 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
83519-59-ACh receptor (muscle) modulating antibodies (if appropriate)
83519-59-AChR ganglionic neuronal antibody (if appropriate)
83519-59-N-type calcium channel antibody (if appropriate)
83519-59-P/Q-type calcium channel antibody (if appropriate)
83519-VGKC (if appropriate)
84182-CRMP-5-IgG Western blot (if appropriate)
84182-Paraneoplastic autoantibody Western blot confirmation (if appropriate)
86255-Amphiphysin (if appropriate)
86255-ANNA-1 (if appropriate)
86255-ANNA-2 (if appropriate)
86255-ANNA-3 (if appropriate)
86255-CRMP-5-IgG (if appropriate)
86255-PCA-1 (if appropriate)
86255-PCA-2 (if appropriate)
86255-PCA-Tr (if appropriate)
86255-DPPCS (if appropriate)
86255-DPPIS (if appropriate)
86255-GL1CS (if appropriate)
86255-GL1IS (if appropriate)
86255-NMDCS (if appropriate)
86255-AMPCS (if appropriate)
86255-GABCS (if appropriate)
86256-NMDIS (if appropriate)
86256-AMPIS (if appropriate)
86256-GABIS (if appropriate)
86256-DPPTS (if appropriate)
86256-GL1TS (if appropriate)
86255-LG1CS (if appropriate)
86255-CS2CS (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PNEFS | Neuroimmunology Ab Follow-up, S | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 84300 | Neuroimmunology Ab Follow-up, S | In Process |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ARMO | ACh Receptor (Muscle) Modulating Ab | No | No |
| GANG | AChR Ganglionic Neuronal Ab, S | No | No |
| AMPCS | AMPA-R Ab CBA, S | No | No |
| AMPIS | AMPA-R Ab IF Titer Assay, S | No | No |
| AMPHS | Amphiphysin Ab, S | No | No |
| ABLOT | Amphiphysin Western Blot, S | No | No |
| AGN1S | Anti-Glial Nuclear Ab, Type 1 | No | No |
| ANN1S | Anti-Neuronal Nuclear Ab, Type 1 | No | No |
| ANN2S | Anti-Neuronal Nuclear Ab, Type 2 | No | No |
| ANN3S | Anti-Neuronal Nuclear Ab, Type 3 | No | No |
| CS2CS | CASPR2-IgG CBA, S | No | No |
| CRMS | CRMP-5-IgG, S | No | No |
| DPPCS | DPPX Ab CBA, S | No | No |
| DPPTS | DPPX Ab IFA Titer, S | No | No |
| DPPIS | DPPX Ab IFA, S | No | No |
| GABCS | GABA-B-R Ab CBA, S | No | No |
| GABIS | GABA-B-R Ab IF Titer Assay, S | No | No |
| LG1CS | LGI1-IgG CBA, S | No | No |
| GL1CS | mGluR1 Ab CBA, S | No | No |
| GL1TS | mGluR1 Ab IFA Titer, S | No | No |
| GL1IS | mGluR1 Ab IFA, S | No | No |
| VGKC | Neuronal (V-G) K+ Channel Ab, S | No | No |
| NMDCS | NMDA-R Ab CBA, S | No | No |
| NMDIS | NMDA-R Ab IF Titer Assay, S | No | No |
| CCN | N-Type Calcium Channel Ab | No | No |
| CCPQ | P/Q-Type Calcium Channel Ab | No | No |
| WBN | Paraneoplastic Autoantibody WBlot,S | No | No |
| PCABP | Purkinje Cell Cytoplasmic Ab Type 1 | No | No |
| PCAB2 | Purkinje Cell Cytoplasmic Ab Type 2 | No | No |
| PCATR | Purkinje Cell Cytoplasmic Ab Type Tr | No | No |
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.