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Test Code 0214023 Zonisamide, Serum

Additional Codes

Mayo Test ID
ZONI

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring zonisamide therapy; recommended for all patients to ensure appropriate dosing

 

Assessing medication compliance

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Zonisamide, S

Specimen Type

Serum Red


Specimen Required


Container/Tube: Red top

Specimen Volume: 1 mL

Collection Instructions: Sample must be centrifuged and serum aliquoted off within 2 hours of draw.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

Serum Gel, SST

 

Reference Values

10-40 mcg/mL

Interpretation

Steady-state zonisamide concentration in a trough specimen drawn just before next dose correlates with patient response, but not with dose. Optimal response to zonisamide occurs when trough zonisamide concentration is in the range of 10 to 40 mcg/mL. Peak serum concentration for zonisamide occurs 2 to 6 hours after dose, and time to peak is affected by food intake.

 

Because carbamazepine activates glucuronidation, patients taking carbamazepine concomitantly with zonisamide have significantly lower zonisamide concentrations compared to patients on the same dose not receiving carbamazepine.

Day(s) and Time(s) Performed

Monday through Saturday

Analytic Time

Same day/1 day

Specimen Retention Time

14 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80203

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ZONI Zonisamide, S 29620-2

 

Result ID Test Result Name Result LOINC Value
83685 Zonisamide, S 29620-2

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.