Home
HelpTest Code 0214023 Zonisamide, Serum
Additional Codes
| Mayo Test ID |
|---|
| ZONI |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring zonisamide therapy; recommended for all patients to ensure appropriate dosing
Assessing medication compliance
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Zonisamide, SSpecimen Type
Serum RedSpecimen Required
Container/Tube: Red top
Specimen Volume: 1 mL
Collection Instructions: Sample must be centrifuged and serum aliquoted off within 2 hours of draw.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Reject Due To
|
Hemolysis |
Mild OK; Gross OK |
|
Lipemia |
Mild OK; Gross OK |
|
Icterus |
Mild OK; Gross OK |
|
Other |
Serum Gel, SST |
Reference Values
10-40 mcg/mL
Interpretation
Steady-state zonisamide concentration in a trough specimen drawn just before next dose correlates with patient response, but not with dose. Optimal response to zonisamide occurs when trough zonisamide concentration is in the range of 10 to 40 mcg/mL. Peak serum concentration for zonisamide occurs 2 to 6 hours after dose, and time to peak is affected by food intake.
Because carbamazepine activates glucuronidation, patients taking carbamazepine concomitantly with zonisamide have significantly lower zonisamide concentrations compared to patients on the same dose not receiving carbamazepine.
Day(s) and Time(s) Performed
Monday through Saturday
Analytic Time
Same day/1 daySpecimen Retention Time
14 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80203
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ZONI | Zonisamide, S | 29620-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 83685 | Zonisamide, S | 29620-2 |
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.