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Test Code 0208686 5-Hydroxyindoleacetic Acid (5-HIAA), 24 Hour, Urine

Additional Codes

Mayo Test ID
HIAA

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

5-Hydroxyindoleacetic Acid, U

Specimen Type

Urine


Necessary Information


24-hour volume is required.

Specimen Required


Patient Preparation:

1. Some medications (see below) could interfere with test results. The ordering provider should decide if any medications should be stopped and when they should be restarted.

2. For 48 hours before patients start their urine collection and during the 24 hours they collect urine:

Limit the following to 1 serving per day:

-Fruits

-Vegetables

-Nuts

-Caffeinated beverages or foods

 

If clinically feasible, discontinue the following medications at least 48 hours before specimen collection:

-Acetaminophen (Tylenol or generic versions)

-Aspirin

-Antihistamines

-Cough syrups

-Cold and flu medications

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube (T068)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a 24-hour urine specimen.

2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 56 days
  Frozen  365 days

Reference Values

≤8 mg/24 hours

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Interpretation

Elevated excretion of 5-hydroxyindoleacetic acid is a probable indicator of the presence of a serotonin-producing tumor, if pharmacological and dietary artifacts have been ruled out.

Day(s) and Time(s) Performed

Monday through Thursday; 11 a.m.

Friday; 2 p.m.

Analytic Time

2 days (not reported on Saturday or Sunday)

Specimen Retention Time

7 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83497

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIAA 5-Hydroxyindoleacetic Acid, U In Process

 

Result ID Test Result Name Result LOINC Value
9248 5-Hydroxyindoleacetic Acid, U 1695-6
TM35 Collection Duration 13362-9
VL33 Urine Volume 3167-4

Urine Preservative Collection Options

Ambient

No

Refrigerated

Yes

Frozen

Yes

6N HCl

Yes (30 mL)

50% Acetic Acid

Preferred (25 mL)

Na2CO3

Yes (5 g)

Toluene

Yes (30 mL)

6N HNO3

Yes (15 mL)

Boric Acid

Yes (10 g)

Thymol (10% in isopropanol)

Yes (10 mL)